el-Girby A H, el-Moneim N A, Khalil S A
Department of Surgery, Faculty of Medicine, Alexandria University, Egypt.
Angiology. 1993 Mar;44(3):183-7. doi: 10.1177/000331979304400303.
This study was performed in 60 patients with the following connective tissue diseases: rheumatoid arthritis (RA--20 patients), systemic lupus erythematosus (SLE--20), and progressive systemic sclerosis (scleroderma = PSS--20). Twenty normal persons served as controls. All patients and controls were subjected to complete history taking, complete physical examination, and laboratory investigations including: rheumatoid factor, anti-DNA, LE cell test, antinuclear factor (ANF), and ECG. Finger arterial blood pressure (FABP) readings using an 8 MHz Doppler flow detector with a 24-mm-diameter cuff at a temperature of 24 degrees C were made in all cases and controls. The mean age of incidence in patients with RA was 37.8 years; in those with SLE, 21.5 years; in those with PSS 34.6 years; and in the control group, 33.7 years. Women were predominant both in the diseases and the control groups. The FABP was measured in all groups and the range of difference between the brachial and finger arterial blood pressure in each group was estimated. In the control group the mean difference was 27.7 mm Hg; in the RA group, 45.8 mm Hg; in the SLE group, 58.1 mm Hg; and in the PSS group, 70.9 mm Hg. There were no significant peripheral vascular changes in the small arteries in the RA group, whereas in the SLE and PSS groups there was a significant difference, which suggests different underlying microvascular changes. The FABP appears to be a diagnostic tool in the diagnosis of PSS and it helps in differentiation between various types of collagen disease in equivocal cases.
本研究对60例患有以下结缔组织疾病的患者进行：类风湿性关节炎（RA——20例患者）、系统性红斑狼疮（SLE——20例）和进行性系统性硬化症（硬皮病=PSS——20例）。20名正常人作为对照。所有患者和对照均进行了完整的病史采集、全面的体格检查以及实验室检查，包括：类风湿因子、抗DNA、LE细胞试验、抗核因子（ANF）和心电图。在所有病例和对照中，使用8兆赫多普勒血流探测器及直径24毫米的袖带，于24摄氏度的温度下测量手指动脉血压（FABP）读数。RA患者的平均发病年龄为37.8岁；SLE患者为21.5岁；PSS患者为34.6岁；对照组为33.7岁。疾病组和对照组中女性均占多数。对所有组测量了FABP，并估算了每组肱动脉和手指动脉血压之间的差值范围。对照组的平均差值为27.7毫米汞柱；RA组为45.8毫米汞柱；SLE组为58.1毫米汞柱；PSS组为70.9毫米汞柱。RA组小动脉无明显外周血管变化，而SLE组和PSS组有显著差异，这提示存在不同的潜在微血管变化。FABP似乎是诊断PSS的一种诊断工具，并且有助于在疑难病例中区分各种类型的胶原病。
