Müller W, Lehner T
Br J Dermatol. 1982 May;106(5):535-44. doi: 10.1111/j.1365-2133.1982.tb04556.x.
A stereological electron microscopical technique was applied to biopsies of oral ulcers from patients with Behçet's syndrome in order to carry out a quantitative analysis of the cellular infiltrate. The results have confirmed the light microscopical qualitative findings of a large number of lymphocytes (67%) but have established that a relatively large proportion of the leukocytes (14%( belong to the monocyte-macrophage series. The virtual absence of plasma cells during the early stages of ulceration and the presence of a large number of lymphocytes and monocytes argue in favour of a type IV cell-mediated immune reaction. As the lesion progresses a type III reaction develops and this might be associated with immune complexes found in the serum of patients with Behçet's syndrome.
为了对细胞浸润进行定量分析，将一种体视学电子显微镜技术应用于白塞病患者口腔溃疡的活检组织。结果证实了光学显微镜下大量淋巴细胞（67%）的定性发现，但也确定相当大比例的白细胞（14%）属于单核细胞-巨噬细胞系列。溃疡早期几乎没有浆细胞，而存在大量淋巴细胞和单核细胞，这支持了IV型细胞介导的免疫反应。随着病变进展，III型反应出现，这可能与白塞病患者血清中发现的免疫复合物有关。
