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Inactivation of Kell blood group antigens by 2-aminoethylisothiouronium bromide.

作者信息

Advani H, Zamor J, Judd W J, Johnson C L, Marsh W L

出版信息

Br J Haematol. 1982 May;51(1):107-15. doi: 10.1111/j.1365-2141.1982.tb07295.x.

DOI:10.1111/j.1365-2141.1982.tb07295.x
PMID:7073987
Abstract

Human red cells incubated with a solution containing 6% 2-aminoethylisothiouronium bromide (AET) lose activity of antigens that are part of, or related to, the Kell blood group system. However, Kx antigen is not inactivated. Studies on a wide range of other blood-group antigens show no other evidence of changes and AET appears to react specifically with red-cell membrane structures that have Kell activity. The AET procedure produces an artificial K0 red cell that can be used in blood group serology, and allows easy recognition of antibodies that are associated with the Kell system. AET has been used by other workers to produce a red cell that has many serological and biochemical characteristics of a PNH cell. Our studies on red cells from PNH patients have not shown any changes in Kell blood-group antigens.

摘要

相似文献

1
Inactivation of Kell blood group antigens by 2-aminoethylisothiouronium bromide.
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2
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Electron microscope study of PNH red cells and AET-treated normal red cells (PNH-like cells).阵发性睡眠性血红蛋白尿症（PNH）红细胞和经氨基乙硫醇（AET）处理的正常红细胞（类PNH细胞）的电子显微镜研究
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引用本文的文献

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2
A human cell-surface glycoprotein that carries Cromer-related blood group antigens on erythrocytes and is also expressed on leucocytes and platelets.一种人类细胞表面糖蛋白，在红细胞上携带与克罗马血型相关的血型抗原，也在白细胞和血小板上表达。
Immunology. 1987 Oct;62(2):307-13.
3
Biochemical and genetic analysis of the OKa blood group antigen.OKa血型抗原的生化与遗传学分析
Immunogenetics. 1988;27(5):322-9. doi: 10.1007/BF00395127.
4
Identification of a cell-surface antigen produced by a gene on human chromosome 3 (cen-q22) and not expressed by Rhnull cells.鉴定一种由人类3号染色体（cen-q22）上的一个基因产生且Rhnull细胞不表达的细胞表面抗原。
Am J Hum Genet. 1987 Dec;41(6):1061-70.
5
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Immunology. 1988 May;64(1):37-43.
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Immune hemolytic anemia and renal failure associated with rifampicin-dependent antibodies with anti-I specificity.免疫性溶血性贫血和肾衰竭与具有抗I特异性的利福平依赖性抗体相关。
Ann Hematol. 1991 Jul;63(1):56-8. doi: 10.1007/BF01714964.
7
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Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6353-7. doi: 10.1073/pnas.88.14.6353.
8
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Immunology. 1992 Mar;75(3):507-12.