[Inactivation of choline receptors induced by membrane depolarization].

It was found that membrane depolarization of Lymnaea stagnalis neurons inhibited the conductance induced by acetylcholine (ACh). This phenomenon (cholinoreceptor inactivation) was shown to be connected with a potential influence on none of the following characteristics: reversal potential (Er) of the ACh-induced currents, affinity of ACh to the receptors, ACh concentration near the receptive membrane surface, and desensitization rate.