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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bregestovksi P D, Bukharaeva E A, Iljin V I

J Physiol. 1979 Dec;297(0):581-95. doi: 10.1113/jphysiol.1979.sp013058.

Desensitization produced by acetylcholine (ACh) in completely isolated Limnaea stagnalis neurones with chloride-selective membrane channels was studied using a voltage-clamp technique. 2. A difference in the time course of the neurone responses to ACh, depending on whether the measured parameter was voltage or current, was observed and explained on the basis of an equivalent electric scheme of the neurone soma membrane. 3. Desensitization onset was shown not to depend on membrane potential in the range of -30 to -120 mV. 4. Variation of external Ca2+, Na+ and Cl- concentrations over a wide range had little influence on the onset of desensitization and recovery from it. 5. An obvious difference is shown to exist between features of desensitization in mollusc neurone and frog muscle end-plate ACh receptors.

利用电压钳技术研究了乙酰胆碱（ACh）在具有氯化物选择性膜通道的完全分离的椎实螺神经元中产生的脱敏作用。2. 根据神经元胞体膜的等效电模型，观察并解释了神经元对ACh反应的时间进程差异，该差异取决于测量参数是电压还是电流。3. 结果表明，脱敏起始不依赖于-30至-120 mV范围内的膜电位。4. 外部Ca2+、Na+和Cl-浓度在很宽范围内变化对脱敏起始及其恢复影响很小。5. 结果显示，软体动物神经元和青蛙肌肉终板ACh受体的脱敏特征存在明显差异。

Bregestovksi P D, Bukharaeva E A, Iljin V I

J Physiol. 1979 Dec;297(0):581-95. doi: 10.1113/jphysiol.1979.sp013058.

Desensitization produced by acetylcholine (ACh) in completely isolated Limnaea stagnalis neurones with chloride-selective membrane channels was studied using a voltage-clamp technique. 2. A difference in the time course of the neurone responses to ACh, depending on whether the measured parameter was voltage or current, was observed and explained on the basis of an equivalent electric scheme of the neurone soma membrane. 3. Desensitization onset was shown not to depend on membrane potential in the range of -30 to -120 mV. 4. Variation of external Ca2+, Na+ and Cl- concentrations over a wide range had little influence on the onset of desensitization and recovery from it. 5. An obvious difference is shown to exist between features of desensitization in mollusc neurone and frog muscle end-plate ACh receptors.

利用电压钳技术研究了乙酰胆碱（ACh）在具有氯化物选择性膜通道的完全分离的椎实螺神经元中产生的脱敏作用。2. 根据神经元胞体膜的等效电模型，观察并解释了神经元对ACh反应的时间进程差异，该差异取决于测量参数是电压还是电流。3. 结果表明，脱敏起始不依赖于-30至-120 mV范围内的膜电位。4. 外部Ca2+、Na+和Cl-浓度在很宽范围内变化对脱敏起始及其恢复影响很小。5. 结果显示，软体动物神经元和青蛙肌肉终板ACh受体的脱敏特征存在明显差异。