Peslin R, Jardin P, Bohadana A, Hannhart B
Bull Eur Physiopathol Respir. 1982 May-Jun;18(3):491-500.
In order to define the minimal frequency response requirements for spirometric measurements, the harmonic content of forced expiratory flow has been assessed in 63 healthy subjects. The amplitude of the harmonics has been found to decrease almost exponentially with increasing frequency. On the average, the cumulated frequency content beyond 10 Hz represented less than 5% of the total frequency content in men, and less than 3% in women. No significant difference has been observed between male smokers and non-smokers. The harmonic content per unit frequency has been found to be correlated to maximal flows at middle and low lung volumes and to maximal mid-expiratory flow up to 4 Hz. For FEV1, maximal flow at 75% of the vital capacity and, particularly, peak expiratory flow rate (PEFR), the correlations were still significant at quite higher frequencies. The data suggest that, except for PEFR, all these indices may be obtained with a good accuracy when the frequency response of the equipment is flat up to 5-7 Hz.
为了确定肺活量测量的最低频率响应要求，对63名健康受试者的用力呼气流量的谐波含量进行了评估。已发现谐波幅度几乎随频率增加呈指数下降。平均而言，超过10Hz的累积频率含量在男性中占总频率含量不到5%，在女性中不到3%。男性吸烟者和非吸烟者之间未观察到显著差异。已发现单位频率的谐波含量与中低肺容量时的最大流量以及高达4Hz的最大呼气中期流量相关。对于第1秒用力呼气容积（FEV1）、肺活量75%时的最大流量，特别是呼气峰值流速（PEFR），在相当高的频率下相关性仍然显著。数据表明，除了PEFR外，当设备的频率响应在5至7Hz范围内保持平坦时，所有这些指标都可以高精度获得。
