大鼠的血液酒精水平：基于体重的腹腔注射剂量产生的结果不一致。
Blood alcohol levels in rats: non-uniform yields from intraperitoneal doses based on body weight.
作者信息
Bloom F, Lad P, Pittman Q, Rogers J
出版信息
Br J Pharmacol. 1982 Jan;75(1):251-4. doi: 10.1111/j.1476-5381.1982.tb08780.x.
Abstract
1 Sprague-Dawley rats (n = 72) weighing from 125 to 450 g were injected intraperitoneally (i.p.) with 16% (w/v) ethanol to provide 1, 2 or 3 g/kg doses. 2 Resulting blood alcohol levels (BALs) demonstrated a general inadequacy of dose/body weight (g/kg) formulations of ethanol to provide uniform BALs in animals of different weights. 3 BAL differences between heavier and lighter rats were not well accounted for by developmental changes in liver weight or alcohol dehydrogenase activity. 4 From the data, a table was derived of more appropriate ethanol injection volumes to produce 0-300 mg% BALs (20 mg% increments) in rats from 100-500 g (10 g increments).
摘要
将体重在125至450克之间的斯普拉格-道利大鼠（n = 72）腹腔注射16%（w/v）乙醇，剂量为1、2或3克/千克。
由此产生的血液酒精浓度（BALs）表明，乙醇的剂量/体重（克/千克）配方一般不足以在不同体重的动物中提供均匀的BALs。
较重和较轻大鼠之间的BAL差异不能很好地用肝脏重量或酒精脱氢酶活性的发育变化来解释。
根据这些数据，得出了一个表格，列出了更合适的乙醇注射体积，以便在100至500克（10克增量）的大鼠中产生0至300毫克%的BALs（20毫克%增量）。
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本文引用的文献
1
Rat liver alcohol dehydrogenase. Purification and properties.
Acta Chem Scand. 1970;25(1):195-205. doi: 10.3891/acta.chem.scand.25-0195.
2
Further studies on the acute toxicity of ethanol in young and old rats: relative importance of pulmonary excretion and total body water.
Toxicol Appl Pharmacol. 1971 Sep;20(1):22-9. doi: 10.1016/0041-008x(71)90085-8.
3
Aging in the rat: longitudinal and cross-sectional studies of body composition.
Am J Physiol. 1973 Dec;225(6):1472-8. doi: 10.1152/ajplegacy.1973.225.6.1472.
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