Finucane B T, Judelman J, Braswell R
Can Anaesth Soc J. 1982 May;29(3):227-30. doi: 10.1007/BF03007121.
Forty-eight healthy patients undergoing routine surgery participated in this double-blind parallel study in which thiopentone sodium and midazolam maleate were compared for induction of anaesthesia. Twelve patients in each group received diazepam premedication. The purpose of this study was three fold; first to compare the efficacy of these two drugs as induction agents using fixed criteria, second to find the optimal dose of midazolam for induction and, finally, to evaluate the effects of diazepam premedication on the induction dose of both drugs. The results showed that adequate induction of anaesthesia was achieved using 0.30 milligrams per kilogram of midazolam and 3.99 milligrams per kilogram of thiopentone. These doses were not altered by pre-operative medication with diazepam. The recovery time was significantly prolonged in those patients who had received midazolam. The shortest recovery time was observed in those patients who had received thiopentone with diazepam. There were four cases of phlebitis in the thiopentone group and two in the midazolam group. In conclusion, midazolam maleate, which is a water soluble benzodiazepine, provided satisfactory induction of anaesthesia at a dose of 0.30 milligrams per kilogram. However, recovery time was significantly prolonged in patients who received midazolam.
48名接受常规手术的健康患者参与了这项双盲平行研究，该研究比较了硫喷妥钠和马来酸咪达唑仑用于诱导麻醉的效果。每组12名患者接受了地西泮术前用药。本研究的目的有三个；第一，使用固定标准比较这两种药物作为诱导剂的疗效；第二，找出诱导用咪达唑仑的最佳剂量；最后，评估地西泮术前用药对两种药物诱导剂量的影响。结果显示，使用0.30毫克/千克的咪达唑仑和3.99毫克/千克的硫喷妥钠可实现充分的麻醉诱导。这些剂量不会因术前使用地西泮而改变。接受咪达唑仑的患者恢复时间显著延长。接受硫喷妥钠和地西泮的患者恢复时间最短。硫喷妥钠组有4例静脉炎，咪达唑仑组有2例。总之，马来酸咪达唑仑是一种水溶性苯二氮䓬类药物，以0.30毫克/千克的剂量可提供令人满意的麻醉诱导。然而，接受咪达唑仑的患者恢复时间显著延长。
