Berggren L, Eriksson I
Acta Anaesthesiol Scand. 1981 Dec;25(6):492-6. doi: 10.1111/j.1399-6576.1981.tb01693.x.
Midazolam, a new water-soluble benzodiazepine, with an elimination half-life of approximately 2 h, was compared with thiopentone for induction of general anaesthesia in a randomized, single-blind study. The patients were 60 healthy women undergoing legal abortion as outpatients. Midazolam provided smooth and reliable induction of anaesthesia with few side-effects. However, the induction time was considerably longer in the midazolam group (82.3 + 6.1) than in the thiopentone group (45.9 +/- 1.7s). The dose of midazolam required for induction was 0.36 +/- 0.01 mg/kg, while that of thiopentone was 6.43 +/- 0.21 mg/kg. Apnoea occurred with a frequency of 10% in the midazolam group and 55% in he thiopentone group, but was of equal duration in both groups. Circulatory conditions were more stable during induction with midazolam, with a slower fall in blood pressure and no change in heart rate. The patient were breathing O2/N2O in proportions of 1:2. To ensure adequate surgical anaesthesia, it was necessary to add halothane for short periods for all patients in the midazolam group and for 79% of the thiopentone group. Postoperatively, all patients who had received midazolam, but none induced with thiopentone, had anterograde amnesia; this lasted for more than 1 h. All patients in both groups could leave the hospital after routine postoperative observation for 3-4 h. Venous tolerance was good for both drugs.
咪达唑仑是一种新型水溶性苯二氮䓬类药物，消除半衰期约为2小时。在一项随机单盲研究中，将其与硫喷妥钠用于全身麻醉诱导进行了比较。患者为60名接受合法门诊人工流产的健康女性。咪达唑仑诱导麻醉平稳可靠，副作用少。然而，咪达唑仑组的诱导时间（82.3±6.1秒）比硫喷妥钠组（45.9±1.7秒）长得多。诱导所需的咪达唑仑剂量为0.36±0.01mg/kg，而硫喷妥钠的剂量为6.43±0.21mg/kg。咪达唑仑组呼吸暂停发生率为10%，硫喷妥钠组为55%，但两组呼吸暂停持续时间相同。咪达唑仑诱导期间循环状况更稳定，血压下降较慢，心率无变化。患者吸入的氧气/氧化亚氮比例为1:2。为确保足够的手术麻醉，咪达唑仑组所有患者和硫喷妥钠组79%的患者都需要短期加用氟烷。术后，所有接受咪达唑仑的患者均出现顺行性遗忘，而硫喷妥钠诱导的患者无一出现；这种遗忘持续超过1小时。两组所有患者在术后常规观察3 - 4小时后均可出院。两种药物的静脉耐受性都良好。
