Corder M P, Jochimsen P R
Cancer. 1982 Jun 15;49(12):2455-8. doi: 10.1002/1097-0142(19820615)49:12<2455::aid-cncr2820491206>3.0.co;2-4.
The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte counts, and of circulating neutrophils and lymphocytes in patients 3-27 months after chemotherapy. Marrow neutrophil reserve studies with prednisolone stimulation again demonstrated significant suppression for the patients who had received chemotherapy. The authors conclude that there is a chronic hematologic toxicity associated with this therapy.
将16例接受基于L - 苯丙氨酸方案辅助化疗两年的乳腺癌女性患者的血液学因素，与13名年龄相仿的正常女性志愿者的血液学因素进行了比较。研究结果显示，化疗后3 - 27个月，患者的平均血红蛋白水平、白细胞计数以及循环中性粒细胞和淋巴细胞均受到显著抑制。用泼尼松龙刺激进行的骨髓中性粒细胞储备研究再次表明，接受化疗的患者受到了显著抑制。作者得出结论，这种治疗存在慢性血液学毒性。
