Jochimsen P R, Corder M P, Lachenbruch P A, Spaight M E
Department of Surgery, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City.
Med Toxicol Adverse Drug Exp. 1988 Jan-Dec;3(1):59-63. doi: 10.1007/BF03259931.
This study examined the question of whether previous exposure to cytostatic drugs by oncology nurses was sufficient to lead to haematological phenotypical subclinical abnormalities which had previously been identified in a population of patients who had received chemotherapy as an adjuvant to breast surgery. A comparison of baseline haematological parameters, and the results of a prednisolone stimulation test, was made between nurses regularly coming into contact with such agents and age-adjusted group of nurses who had not been exposed. Although there is a persistent trend toward lower neutrophils, platelets, monocytes and neutrophil reserves in the nurses who handled antineoplastic agents, a statistically significant decrement in these parameters was not identified. Such a finding should help to reassure individuals who have had similar exposure, but does not negate the importance of following published recommended guidelines for the handling and dispensing of antineoplastic agents.
本研究探讨了肿瘤护理人员既往接触细胞毒性药物是否足以导致血液学表型亚临床异常的问题，此前在接受化疗作为乳腺癌手术辅助治疗的患者群体中已发现此类异常。对经常接触此类药物的护士与未接触过的年龄匹配护士组的基线血液学参数及泼尼松龙刺激试验结果进行了比较。尽管接触抗肿瘤药物的护士中，中性粒细胞、血小板、单核细胞及中性粒细胞储备持续呈下降趋势，但这些参数并未出现统计学上的显著下降。这一发现应有助于让有类似接触经历的人安心，但并不否定遵循已发表的抗肿瘤药物处理和调配推荐指南的重要性。
