Lechin F, van der Dijs B, Bentolila A, Peña F
Am J Gastroenterol. 1978 Jun;69(6):662-8.
Dihydroergotamine (dhe) (or phentolamine), an alpha-adrenergic blocking agent, induced important changes on the CCK-stimulated gallbladder emptying of 70 volunteer subjects. Two cholecystograms were performed with 10-day intervals in each subject. The first cholecystogram showed gallbladder emptying provoked by a test meal (35 subjects or by 0.5 U. CCK Kg. injected intravenously (35 subjects). During the second cholecystogram 1 mg. of DHE was injected intramuscularly 45 minutes befor the cholecystokinetic stimulus. The drug counteracted the gallbladder emptying induced by both endogenous and exogenous CCK. The effect was more pronounced when DHE was administered prior to the test meal stimulus than before CCK administration. This difference could be explained by a delayed gastric emptying induced by the alpha-adrenergic blockade. Our results suggest that the lack of gallbladder emptying could be due to the relaxation of this organ, in addition to a duodenal spasticity induced by DHE (or phentolamine).
双氢麦角胺（DHE）（或酚妥拉明），一种α-肾上腺素能阻滞剂，在70名志愿者中对胆囊收缩素（CCK）刺激的胆囊排空产生了重要影响。每位受试者每隔10天进行两次胆囊造影。第一次胆囊造影显示，通过试餐（35名受试者）或静脉注射0.5单位CCK/千克（35名受试者）引起胆囊排空。在第二次胆囊造影期间，在胆囊收缩刺激前45分钟肌肉注射1毫克DHE。该药物抵消了内源性和外源性CCK诱导的胆囊排空。当在试餐刺激之前给予DHE时，其效果比在给予CCK之前更明显。这种差异可以用α-肾上腺素能阻滞引起的胃排空延迟来解释。我们的结果表明，胆囊排空不足可能是由于该器官的松弛，此外还有DHE（或酚妥拉明）引起的十二指肠痉挛。
