Harouchi A, Benchemsi N, Benouhoud M
Chir Pediatr. 1982 Mar-Apr;23(2):109-13.
Because of the risk of overwhelming sepsis following splenectomy, and since it is possible to reduce the splenic function while preserving the spleen, the treatment of various hematologic disorders by splenic artery ligation has been attempted in 11 children, among whom 3 under 5 years of age. 3 patients had thalassemia, 4 had hereditary spherocytosis and 4 others suffered from secondary hypersplenism. One patient died of overlooked splenic necrosis. The other patients are well, with an average follow-up of 19 mo. The aim of this study is to find out whether the desarterization produces the expected results and is well tolerated and whether the desarterialized spleen still preserves its ability to protect the host against infection. The satisfactory treatment of hereditary spherocytosis and secondary hypersplenism would indicate that splenic artery ligation offers an alternative to splenectomy, especially in children under 5 year old.
由于脾切除术后存在发生严重败血症的风险，并且在保留脾脏的同时降低脾功能是可行的，因此对11名儿童尝试了通过脾动脉结扎术治疗各种血液系统疾病，其中3名年龄在5岁以下。3例患有地中海贫血，4例患有遗传性球形红细胞增多症，另外4例患有继发性脾功能亢进。1例患者死于被忽视的脾坏死。其他患者情况良好，平均随访19个月。本研究的目的是弄清楚脾动脉结扎术是否产生预期效果且耐受性良好，以及去动脉化的脾脏是否仍保留其保护宿主免受感染的能力。遗传性球形红细胞增多症和继发性脾功能亢进的满意治疗将表明脾动脉结扎术为脾切除术提供了一种替代方法，尤其是对于5岁以下的儿童。
