Papadopoulos N M, McFarlin D E, Patronas N J, McFarland H F, Costello R
Am J Clin Pathol. 1987 Sep;88(3):365-8. doi: 10.1093/ajcp/88.3.365.
Ninety-five patients suspected of having multiple sclerosis (MS) were evaluated by medical history and neurologic examination. Based on this evidence they were divided into three groups: clinically definite MS, not-definite MS, and not MS. The adjunct tests, chemical analysis, and magnetic resonance imaging (MRI), were also performed to assess the diagnosis of MS. Chemical analyses of paired serum and cerebrospinal fluid (CSF) samples were performed to identify oligoclonal immunoglobulin bands and to estimate both the albumin quotient and the IgG index. A positive correlation was found between the chemical test results and definite MS in 73 of 73 cases. In 11 of 12 cases of not-definite MS the chemical results were positive for MS. A positive correlation was also found between ten of ten cases that were not MS and negative chemical test results. MRI scans were positive for MS in 48 of 51 clinically definite MS cases and in 4 of 4 not-definite MS cases. MRI scans were negative for MS in five of six cases that were not MS. These findings demonstrate that combined determinations of serum and CSF proteins by simple zone electrophoresis and commercial immunochemical tests can be useful laboratory aids in the diagnosis of MS. The MRI scans provide additional evidence to support the diagnosis of MS.
95名疑似患有多发性硬化症（MS）的患者接受了病史和神经系统检查评估。基于这些证据，他们被分为三组：临床确诊的MS、未确诊的MS和非MS。还进行了辅助检查、化学分析和磁共振成像（MRI）以评估MS的诊断。对配对的血清和脑脊液（CSF）样本进行化学分析，以识别寡克隆免疫球蛋白带，并估计白蛋白商和IgG指数。在73例病例中，化学检测结果与确诊的MS之间存在正相关。在12例未确诊的MS病例中有11例化学结果呈MS阳性。在10例非MS病例中，化学检测结果与阴性之间也存在正相关。在51例临床确诊的MS病例中有48例MRI扫描呈MS阳性，在4例未确诊的MS病例中有4例呈阳性。在6例非MS病例中有5例MRI扫描呈MS阴性。这些发现表明，通过简单的区带电泳和商业免疫化学检测联合测定血清和脑脊液蛋白质，可作为MS诊断中有用的实验室辅助手段。MRI扫描为支持MS诊断提供了额外证据。
