Grossman A, West S, Williams J, Evans J, Rees L H, Besser G M
Clin Endocrinol (Oxf). 1982 Mar;16(3):317-20. doi: 10.1111/j.1365-2265.1982.tb00722.x.
The role of endogenous opiate peptides in puerperal hyperprolactinaemia, and in the control of TSH in hypothyroidism, has been investigated. Although exogenous opioids raise prolactin and TSH levels, 16 mg naloxone administered to women on days 2-4 of the puerperium produced no significant change in serum prolactin and the same dose of naloxone had no significant effect on serum TSH in six primary hypothyroid patients. There is little evidence that endogenous opioid peptides are major modulators of prolactin or TSH in man under these conditions.
内源性阿片肽在产后高泌乳素血症以及甲状腺功能减退症中促甲状腺激素（TSH）调控方面的作用已得到研究。尽管外源性阿片类药物会使泌乳素和TSH水平升高，但在产褥期第2 - 4天给女性注射16毫克纳洛酮后，血清泌乳素未出现显著变化，且相同剂量的纳洛酮对6例原发性甲状腺功能减退患者的血清TSH也无显著影响。几乎没有证据表明在这些情况下内源性阿片肽是人体泌乳素或TSH的主要调节因子。
