Cook C E, Brine D R, Quin G D, Perez-Reyes M, Di Guiseppi S R
Clin Pharmacol Ther. 1982 May;31(5):635-41. doi: 10.1038/clpt.1982.88.
Five men who smoked parsley cigarettes containing 100 micrograms of [3H]-phencyclidine hydrochloride (PCP.HCl) inhaled 69 +/- 5(SEM) % of the total radioactivity in the cigarette. Both PCP and its pyrolysis product, 1-phenylcyclohexene (PC), were found and measured in plasma. Calculations based on the assumption that the ratio of these two products was the same as in simulated smoking studies and based on either area under the curve or urinary excretion of PCP indicated that most of the PCP in smoke was absorbed. Mean half-life (t1/2) of PCP (24 +/- 7 hr, harmonic mean 18 hr) and ratios of metabolites in plasma and urine were close to those previously reported after intravenous and oral doses. A second peak in PCP plasma concentrations was observed, possible due to show efflux from the lungs. PC plasma concentrations (maximum 0.35 +/- 0.06 pmol/ml) were lower than those of PCP (maximum 0.62 +/- 0.09 pmol/ml) and its mean t1/2 (14 +/- 3 hr, harmonic mean 12 h) was shorter than that of PCP. Only traces of PC were found in urine. Only small amounts of metabolites from PC were found nonconjugated in plasma (to about 0.1 pmol/ml) or urine (less than 2% of radioactivity), but larger quantities were found as enzyme-hydrolyzable conjugates in urine (6% of radioactivity). Conjugates were also found in plasma (to about 0.12 pmol/ml).
五名吸食含有100微克盐酸[3H]-苯环利定（PCP.HCl）的欧芹香烟的男性吸入了香烟中69±5（SEM）%的总放射性物质。在血浆中发现并测量了PCP及其热解产物1-苯基环己烯（PC）。基于这两种产物的比例与模拟吸烟研究中相同的假设，并基于曲线下面积或PCP的尿排泄量进行的计算表明，烟雾中的大部分PCP被吸收。PCP的平均半衰期（t1/2）为24±7小时，调和平均数为18小时，血浆和尿液中代谢物的比例与先前静脉注射和口服剂量后报道的相近。观察到PCP血浆浓度出现第二个峰值，可能是由于从肺部缓慢流出所致。PC血浆浓度（最高0.35±0.06 pmol/ml）低于PCP血浆浓度（最高0.62±0.09 pmol/ml），其平均t1/2（14±3小时，调和平均数12小时）比PCP的短。尿液中仅发现微量的PC。在血浆（约0.1 pmol/ml）或尿液（放射性的不到2%）中未结合形式的PC代谢物仅发现少量，但在尿液中作为可被酶水解的结合物发现了大量（放射性的6%）。血浆中也发现了结合物（约0.12 pmol/ml）。
