Martin B R, Freeman A S
Fed Proc. 1983 Jun;42(9):2561-5.
Phencyclidine (PCP) is a drug that is frequently misused by smoking. Recent popularity of PCP abuse by this method probably stems from the fact that smoking allows users to titrate themselves as well as reduce the incidence of adverse reactions. PCP is pyrolyzed at high temperatures to form predominantly 1-phenyl-1-cyclohexene (PC). Piperidine and related products are formed in smaller quantities. Smoke from cigarettes impregnated with PCP contains approximately equimolar concentrations of PCP and PC. It has been shown that PCP and PC are present in the circulation of individuals after they smoke PCP-laden cigarettes. In addition, PCP and PC can be found in plasma as well as in all major organs of mice exposed to smoke from PCP-containing cigarettes. The brain concentrations of PC in mice are comparable to those of PCP immediately after exposure but the PC levels decline somewhat more rapidly. Actually the time course of behavioral activity correlates better with PCP levels than with PC levels. In addition, PC and its major metabolites, as well as piperidine, are considerably less active behaviorally than PCP, which suggests that pyrolysis represents an inactivation process for PCP. However, a total lack of contribution of pyrolysis products to PCP's actions has not been ruled out.
苯环己哌啶（PCP）是一种常被滥用的药物，通常通过吸烟来使用。近期通过这种方式滥用PCP的现象增多，可能是因为吸烟便于使用者自行控制用量，同时还能减少不良反应的发生率。PCP在高温下热解，主要生成1-苯基-1-环己烯（PC）。哌啶及相关产物的生成量较少。吸食浸有PCP的香烟所产生的烟雾中，PCP和PC的浓度大致相等。研究表明，人们吸食含有PCP的香烟后，PCP和PC会进入其血液循环。此外，在接触含PCP香烟烟雾的小鼠的血浆及所有主要器官中都能检测到PCP和PC。小鼠接触烟雾后，大脑中的PC浓度在接触后即刻与PCP相当，但PC水平下降得更快。实际上，行为活动的时间进程与PCP水平的相关性比与PC水平的相关性更好。此外，PC及其主要代谢产物，以及哌啶，在行为上的活性比PCP低得多，这表明热解是PCP的一种失活过程。然而，尚未排除热解产物对PCP作用完全没有影响的可能性。
