Effect of tranexamic acid on the fibrinolytic activity of human uterine fluid.

The normally occurring fibrinolytic activity of uterine fluid was used to evaluate the possibility of influencing fibrinolytic enzymes liberated in the uterine cavity in humans. Oral and intravenous administration of a synthetic fibrinolytic inhibitor, tranexamic acid, was found to significantly suppress the fibrinolytic activity of uterine fluid during the luteal phase. The significance of this observation is discussed in relation to the possible participation of fibrinolytic enzymes during the implantation process in humans as in some other species.