Bakka A, Johnsen A S, Endresen L, Rugstad H E
Experientia. 1982 Mar 15;38(3):381-3. doi: 10.1007/BF01949406.
An endogenous cytoplasmic protein, metallothionein (MT) apparently gave rise to radioresistance in 2 different cell lines. A dose reduction factor of 1.9 was achieved in MT-containing cells. MT accounted for a 3-4 fold increase of total sulfhydryl groups in the resistant cell strains, compared to the non-resistant lines from which they were derived. The protein is rich in cysteine (30%), an amino acid known to give radioprotection when administered exogenously. Glutathione levels and cell-cycle phase distribution showed no marked difference between resistant and corresponding non-resistant cells.
金属硫蛋白（MT）是一种内源性细胞质蛋白，显然它在两种不同的细胞系中产生了辐射抗性。含MT的细胞实现了1.9的剂量降低因子。与产生它们的非抗性细胞系相比，MT使抗性细胞株中的总巯基增加了3至4倍。该蛋白富含半胱氨酸（30%），半胱氨酸是一种已知在外源给药时能提供辐射防护的氨基酸。抗性细胞与相应的非抗性细胞之间的谷胱甘肽水平和细胞周期阶段分布没有显著差异。
