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Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination.

作者信息

Satoh M, Naganuma A, Imura N

机构信息

Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Cancer Chemother Pharmacol. 1988;21(2):176-8. doi: 10.1007/BF00257369.

DOI:10.1007/BF00257369
PMID:3349566
Abstract

The protective effects of metallothionein (MT) preinduction by bismuth subnitrate (BSN) against the renal toxicity of cis-diamminedichloroplatinum (cis-DDP), the cardiotoxicity of adriamycin (ADR), and the lethal and bone marrow toxicities of these drugs were observed in mice receiving cis-DDP and ADR simultaneously. Preinduction of MT biosynthesis by BSN, which is currently used as an antidiarrheal drug, did not affect the antitumor activities of the two drugs, suggesting that the beneficial effects of the preinduction of MT biosynthesis by BSN may be applicable for therapy involving cis-DDP and ADR, either alone or in combination.

摘要

相似文献

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Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination.
Cancer Chemother Pharmacol. 1988;21(2):176-8. doi: 10.1007/BF00257369.
2
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3
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Experientia Suppl. 1987;52:655-60. doi: 10.1007/978-3-0348-6784-9_70.
4
Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.通过诱导金属硫蛋白合成预防顺二氯二氨铂（II）的致死性和肾毒性，同时不损害其在小鼠中的抗肿瘤活性。
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5
Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis-diamminedichloroplatinum.柠檬酸盐可增强口服碱式硝酸铋对顺二氨二氯铂肾毒性的保护作用。
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6
Effect of preinduction of metallothionein synthesis on clastogenicity of anticancer drugs in mice.
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7
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Anticancer Res. 1992 Nov-Dec;12(6B):2303-7.

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本文引用的文献

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Radioresistance in cells with high content of metallothionein.金属硫蛋白含量高的细胞中的辐射抗性
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Increased resistance to chlorambucil in cultured cells with a high concentration of cytoplasmic metallothionein.在具有高浓度细胞质金属硫蛋白的培养细胞中对苯丁酸氮芥的抗性增加。
铋卟啉通过意外的非金属硫蛋白依赖机制拮抗顺铂诱导的肾毒性。
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UV-vis absorption spectrum of a novel Ru(II) complex intercalated in DNA: [Ru(2,2'-bipy)(dppz)(2,2'-ArPy)]⁺.嵌入DNA中的新型钌（II）配合物[Ru(2,2'-联吡啶)(二吡啶并菲)(2,2'-芳基吡啶)]⁺的紫外-可见吸收光谱
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HeLa cell transformants overproducing mouse metallothionein show in vivo resistance to cis-platinum in nude mice.过量产生小鼠金属硫蛋白的HeLa细胞转化体在裸鼠体内对顺铂具有抗性。
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Cisplatin-induced renal toxicity and toxicity-modulating strategies: a review.顺铂诱导的肾毒性及毒性调节策略：综述
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Effect of bismuth nitrate given in combination with cis-diamminedichloroplatinum(II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor.硝酸铋与顺二氯二氨合铂（II）联合给药对接种人膀胱肿瘤的裸鼠体内后者抗肿瘤活性及肾毒性的影响
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Modulation of cis-diamminedichloroplatinum(II) resistance: a review.顺二氯二氨合铂（II）耐药性的调控：综述
Br J Cancer. 1992 Aug;66(2):227-38. doi: 10.1038/bjc.1992.249.
Cancer Res. 1983 Jun;43(6):2918-26.
4
Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen.NADPH 细胞色素 P-450 还原酶将阿霉素还原为无半醌自由基，在由分子氧介导的反应中产生 DNA 裂解。
J Biol Chem. 1981 May 25;256(10):4747-56.
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Platinum compounds: a new class of potent antitumour agents.铂化合物：一类新型强效抗肿瘤药物。
Nature. 1969 Apr 26;222(5191):385-6. doi: 10.1038/222385a0.
6
Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration.四氯化碳给药后大鼠肝脏中脂质过氧化的早期发生。
Exp Mol Pathol. 1968 Oct;9(2):271-8. doi: 10.1016/0014-4800(68)90041-5.
7
Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.超氧化物歧化酶：改进的测定方法及一种适用于丙烯酰胺凝胶的测定方法。
Anal Biochem. 1971 Nov;44(1):276-87. doi: 10.1016/0003-2697(71)90370-8.
8
Adriamycin. A new anticancer drug with significant clinical activity.阿霉素。一种具有显著临床活性的新型抗癌药物。
Ann Intern Med. 1974 Feb;80(2):249-59. doi: 10.7326/0003-4819-80-2-249.
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Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice.
Toxicol Lett. 1985 Feb-Mar;24(2-3):203-7. doi: 10.1016/0378-4274(85)90058-x.
10
Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.通过诱导金属硫蛋白合成预防顺二氯二氨铂（II）的致死性和肾毒性，同时不损害其在小鼠中的抗肿瘤活性。
Cancer Res. 1987 Feb 15;47(4):983-7.