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半胱氨酸对新生大鼠大脑中氨基酸的影响。

Cysteine-induced effect on amino acids in neonatal rat brain.

作者信息

Misra C H

出版信息

Experientia. 1982 Mar 15;38(3):383-4. doi: 10.1007/BF01949407.

DOI:10.1007/BF01949407
PMID:7075736
Abstract

In neonatal rat brain 6 h after s.c. administration of L-cysteine, an increase was observed in most of the amino acids with the exception of glutamic acid, aspartic acid, phenylalanine, sarcosine, glutamine, hydroxyproline and phosphoethanolamine compared to age-matched saline controls. Cysteine was not present at detectable levels in control brain but was found to be 0.38 to 0.52 mumole/g of fresh brain tissue in 2- and 4-day-old rats respectively after cysteine treatment.

摘要

在新生大鼠脑内,皮下注射L-半胱氨酸6小时后,与年龄匹配的生理盐水对照组相比,除谷氨酸、天冬氨酸、苯丙氨酸、肌氨酸、谷氨酰胺、羟脯氨酸和磷酸乙醇胺外,大多数氨基酸的含量均有所增加。对照组脑内未检测到半胱氨酸,但在半胱氨酸处理后的2日龄和4日龄大鼠中,分别发现新鲜脑组织中的半胱氨酸含量为0.38至0.52微摩尔/克。

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本文引用的文献

1
THE BRAIN BARRIER SYSTEM. V. STEREOSPECIFICITY OF AMINO ACID UPTAKE, EXCHANGE AND EFFLUX.脑屏障系统。V. 氨基酸摄取、交换和流出的立体特异性
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A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids.一种在其他天然存在的氨基酸存在下直接测定半胱氨酸的分光光度法。
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Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine.幼鼠经口摄入谷氨酸、天冬氨酸或半胱氨酸后的脑损伤。
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Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system.含酸性和硫氨基酸对幼鼠中枢神经系统的细胞毒性作用。
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Cysteine-induced brain damage in infant and fetal rodents.半胱氨酸诱导的幼鼠和胎鼠脑损伤。
Brain Res. 1972 Oct 13;45(1):309-13. doi: 10.1016/0006-8993(72)90243-0.
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L-dihydroxyphenylalanine: effect on levels of amino acids in rat brain.L-二羟基苯丙氨酸:对大鼠脑内氨基酸水平的影响
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