Tatevosian A T, Gevorkian Zh S, Oganesian A S, Mirzoian S A
Farmakol Toksikol. 1982 Mar-Apr;45(2):48-52.
It was found that GABA and sodium hydroxybutyrate are capable to prevent gastric ulcers. While protecting the animals from experimental ulcers both the substances display an ability to increase the content of ATP in the gastric wall. ATP that prevents the occurrence of experimental gastric ulcers enhances 14-leucine incorporation into proteins of gastric tissues. It was demonstrated in experiments ulcer prevention that under the effect of 32P-ATP the content of phosphorylated proteins in gastric tissues rises more than 2-fold. This circumstances ensures the increased resistance of the gastric mucosa to the action of proteolytic enzymes. Enhancement of oxygen consumption by the tissues should be also regarded as one of the factors determining high resistance of the mucosa to proteolysis.
研究发现，γ-氨基丁酸（GABA）和羟丁酸钠能够预防胃溃疡。在保护动物免受实验性溃疡侵害时，这两种物质均表现出增加胃壁中三磷酸腺苷（ATP）含量的能力。能够预防实验性胃溃疡的ATP可增强亮氨酸-14掺入胃组织蛋白质中的能力。在预防溃疡的实验中表明，在32P-ATP的作用下，胃组织中磷酸化蛋白质的含量增加了两倍多。这种情况可确保胃黏膜对蛋白水解酶作用的抵抗力增强。组织耗氧量的增加也应被视为决定黏膜对蛋白水解具有高抵抗力的因素之一。
