致命性急性肝衰竭期间肝细胞增殖的证据。
Evidence for liver cell proliferation during fatal acute liver failure.
作者信息
Milandri M, Gaub J, Ranek L
出版信息
Gut. 1980 May;21(5):423-7. doi: 10.1136/gut.21.5.423.
Abstract
Liver cell regeneration was assessed by determining the mitotic index and the frequency of liver cells with interploid DNA values in livers from patients dying from fulminant hepatitis. For comparison, the same parameters were determined in patients with uncomplicated hepatitis. We found comparable levels of regeneration in the two groups, indicating that the rate of liver cell destruction is a major determinant in the prognosis of acute liver failure. Accordingly, measures to prevent liver cell necrosis seem at least as important as stimulation of regeneration. Judged from available experimental evidence, substances with documented hepatotrophic effect in animals, such as insulin and glucagon, may therefore not be effective in acute liver failure unless the patient has impaired secretion of these substances.
摘要
通过测定暴发性肝炎死亡患者肝脏的有丝分裂指数和具有非整倍体DNA值的肝细胞频率来评估肝细胞再生情况。作为对照，对非复杂性肝炎患者测定相同参数。我们发现两组的再生水平相当，这表明肝细胞破坏率是急性肝衰竭预后的主要决定因素。因此，预防肝细胞坏死的措施似乎至少与促进再生一样重要。根据现有实验证据判断，在动物中有明确肝营养作用的物质，如胰岛素和胰高血糖素，因此在急性肝衰竭中可能无效，除非患者这些物质的分泌受损。
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