肝病男性体内的孕酮、催乳素与男性乳房发育症
Progesterone, prolactin, and gynaecomastia in men with liver disease.
作者信息
Farthing M J, Green J R, Edwards C R, Dawson A M
出版信息
Gut. 1982 Apr;23(4):276-9. doi: 10.1136/gut.23.4.276.
Abstract
Plasma progesterone was raised in 36 of 50 (72%) men with liver disease compared with 20 healthy male control subjects. Plasma progesterone was significantly higher in men with non-alcoholic cirrhosis with gynaecomastia than those without, but no similar relationship was found in men with alcoholic fatty change and alcoholic cirrhosis. Hyperprolactinaemia was found in 14% of men with liver disease but levels were unrelated to the presence of gynaecomastia. Increased circulating levels of progesterone and prolactin alone do not explain the development of gynaecomastia in patients with liver disease, but progesterone may be an additional factor acting in association with the known disturbances of other sex steroids.
摘要
与20名健康男性对照受试者相比，50名肝病男性中有36名（72%）的血浆孕酮水平升高。患有伴有男性乳房发育的非酒精性肝硬化的男性，其血浆孕酮水平显著高于未患该病的男性，但在患有酒精性脂肪变性和酒精性肝硬化的男性中未发现类似关系。14%的肝病男性存在高催乳素血症，但其水平与男性乳房发育的存在无关。仅孕酮和催乳素循环水平升高并不能解释肝病患者男性乳房发育的发生，但孕酮可能是与其他性类固醇已知紊乱相关的一个额外因素。
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