药物对大鼠实验性急性胰腺炎肺部变化的影响。
Effect of drugs on the pulmonary changes in experimental acute pancreatitis in the rat.
作者信息
Berry A R, Taylor T V
出版信息
Gut. 1982 Jun;23(6):481-4. doi: 10.1136/gut.23.6.481.
Respiratory complications of acute pancreatitis are well recognised and are closely related to a poor prognosis. Using an experimental model in the rat, a decrease in lung compliance and an increase in lung weight were produced in acute pancreatitis. The effects of dexamethasone, heparin, and aspirin on these changes were studied. The mean specific lung compliance was reduced by 16% in the pancreatitis group compared with the control group (p less than 0.05) and this change was abolished by dexamethasone (p less than 0.02), heparin (p less than 0.01), and aspirin (p less than 0.001). Percentage lung weight (as percentage of total body weight) was raised by 22% in the pancreatitis group compared with the sham operation group (p less than 0.01) and this change was abolished by heparin (p less than 0.01) and aspirin (p less than 0.05), but not affected by dexamethasone (p less than 0.5). The results indicate that 'stiff' and heavy lungs occur in experimental acute pancreatitis. The fact that these changes are abolished by heparin and improved by aspirin suggests that intrapulmonary fibrin deposition is a factor in the pathogenesis of the important respiratory complications of this condition.
急性胰腺炎的呼吸并发症已得到充分认识，且与预后不良密切相关。在大鼠实验模型中，急性胰腺炎会导致肺顺应性降低和肺重量增加。研究了地塞米松、肝素和阿司匹林对这些变化的影响。与对照组相比，胰腺炎组的平均比肺顺应性降低了16%（p<0.05），而地塞米松（p<0.02）、肝素（p<0.01）和阿司匹林（p<0.001）可消除这种变化。与假手术组相比，胰腺炎组的肺重量百分比（占总体重的百分比）增加了22%（p<0.01），肝素（p<0.01）和阿司匹林（p<0.05）可消除这种变化，但地塞米松对其无影响（p<0.5）。结果表明，实验性急性胰腺炎会出现肺“僵硬”和重量增加的情况。肝素可消除这些变化，阿司匹林可改善这些变化，这一事实表明肺内纤维蛋白沉积是该疾病重要呼吸并发症发病机制中的一个因素。
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