Friedrich E A, Aulenbacher P, Schlepper-Schäfer J, Süss R
Immunol Lett. 1982 Mar;4(3):167-70. doi: 10.1016/0165-2478(82)90030-x.
Chemical-modified erythrocytes (trinitrobenzene-modified erythrocytes (TNB-RBC)) are trapped in vivo rapidly by liver macrophages (Kupffer cells). The liver homing of TNB-RBC is dependent on the concentration of TNB-residues coupled to the surface of RBC. High concentrations induce liver homing, low concentrations spleen homing.
化学修饰红细胞(三硝基苯修饰红细胞(TNB-RBC))在体内会迅速被肝脏巨噬细胞(枯否细胞)捕获。TNB-RBC的肝脏归巢取决于与红细胞表面偶联的TNB残基浓度。高浓度诱导肝脏归巢,低浓度诱导脾脏归巢。