细胞毒性T细胞能够区分三硝基苯基修饰的同基因细胞和二硝基苯基修饰的同基因细胞。
Cytotoxic T cells distinguish between trinitrophenyl- and dinitrophenyl-modified syngeneic cells.
作者信息
Forman J
出版信息
J Exp Med. 1977 Aug 1;146(2):600-5. doi: 10.1084/jem.146.2.600.
Abstract
Spleen cells sensitized against trinitrophenyl (TNP)-modified stimulator cells displayed a cytotoxic effect against syngeneic TNP-modified but not dinitrophenyl (DNP)-modified target cells. The same finding was observed in the opposite direction; that is, effector cells sensitized against DNP-modified stimulator cells did not cross kill TNP-modified targets. The specificity of the anti-TNP effector cells was confirmed in a cold target competition assay. Presensitization in vivo with hapten-modified cells followed by rechallenge and testing in vitro did not alter the specificity of the response between the haptens. These data indicate that the receptor(s) on the cytotoxic T cell can distinguish between two closely related haptenic molecules.
摘要
对三硝基苯基（TNP）修饰的刺激细胞致敏的脾细胞，对同基因的TNP修饰的靶细胞具有细胞毒性作用，但对二硝基苯基（DNP）修饰的靶细胞则无此作用。在相反的实验中也观察到了相同的结果；也就是说，对DNP修饰的刺激细胞致敏的效应细胞不会交叉杀伤TNP修饰的靶细胞。在冷靶竞争试验中证实了抗TNP效应细胞的特异性。用半抗原修饰的细胞在体内进行预致敏，然后在体外再次激发和测试，并没有改变半抗原之间反应的特异性。这些数据表明，细胞毒性T细胞上的受体能够区分两种密切相关的半抗原分子。
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2
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