抗磷酸胆碱抗体对小鼠感染肺炎链球菌的保护作用。
Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
作者信息
Yother J, Forman C, Gray B M, Briles D E
出版信息
Infect Immun. 1982 Apr;36(1):184-8. doi: 10.1128/iai.36.1.184-188.1982.
Abstract
Anti-phosphocholine (PC) antibody mediated protection against many strains of Streptococcus pneumoniae, and hybridoma anti-PC antibodies protected mice from fatal infections with types 1 and 3 S. pneumoniae. Live types 1, 3, 5, 6A, and 19F S. pneumoniae had similar amounts of surface PC accessible to antibody. Furthermore, mice expressing the X-linked immunodeficiency (xid) of the CBA/N strain were found to be more susceptible to infection with S. pneumoniae of types 3, 6A, and 19F than were immunologically normal mice. The only exception to these results was with the type 5 strain, which was highly virulent for both xid and normal mice. In addition, we were unable to protect mice against infection with the type 5 strain by using anti-PC antibody.
摘要
抗磷酸胆碱（PC）抗体介导对多种肺炎链球菌菌株的保护作用，杂交瘤抗PC抗体可保护小鼠免受1型和3型肺炎链球菌的致命感染。活的1型、3型、5型、6A 型和19F型肺炎链球菌表面可被抗体识别的PC量相似。此外，发现表达CBA/N品系X连锁免疫缺陷（xid）的小鼠比免疫正常的小鼠更易感染3型、6A 型和19F型肺炎链球菌。这些结果的唯一例外是5型菌株，它对xid小鼠和正常小鼠都具有高毒性。此外，我们无法用抗PC抗体保护小鼠免受5型菌株的感染。
相似文献
1
Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.抗磷酸胆碱抗体对小鼠感染肺炎链球菌的保护作用。
Infect Immun. 1982 Apr;36(1):184-8. doi: 10.1128/iai.36.1.184-188.1982.
2
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.在正常小鼠血清中发现的抗磷酸胆碱抗体可预防3型肺炎链球菌的静脉感染。
J Exp Med. 1981 Mar 1;153(3):694-705. doi: 10.1084/jem.153.3.694.
3
Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.抗磷酸胆碱抗体VH1重链V-D连接区的序列变化会改变对肺炎链球菌的结合及保护作用。
Int Immunol. 1997 May;9(5):665-77. doi: 10.1093/intimm/9.5.665.
4
5
Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types.磷胆碱结合抗体赋予小鼠抗肺炎球菌感染的能力：磷胆碱结合的特异性及其与多种类型的关系。
Infect Immun. 1983 Feb;39(2):993-9. doi: 10.1128/iai.39.2.993-999.1983.
6
Antibody protection in aging: influence of idiotypic repertoire and antibody binding activity to a bacterial antigen.衰老过程中的抗体保护：独特型库及抗体与细菌抗原结合活性的影响
Exp Mol Pathol. 1995 Apr;62(2):99-108. doi: 10.1006/exmp.1995.1011.
7
A novel phosphocholine antigen protects both normal and X-linked immune deficient mice against Streptococcus pneumoniae. Comparison of the 6-O-phosphocholine hydroxyhexanoate-conjugate with other phosphocholine-containing vaccines.一种新型磷酸胆碱抗原可保护正常小鼠和X连锁免疫缺陷小鼠免受肺炎链球菌感染。6-O-磷酸胆碱羟基己酸酯缀合物与其他含磷酸胆碱疫苗的比较。
J Immunol. 1995 Apr 1;154(7):3373-82.
8
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.T15 独特型的抗磷酸胆碱抗体对肺炎链球菌具有最佳保护作用。
J Exp Med. 1982 Oct 1;156(4):1177-85. doi: 10.1084/jem.156.4.1177.
9
Induction of phosphocholine-specific antibodies in X-linked immune deficient mice: in vivo protection against a Streptococcus pneumoniae challenge.在X连锁免疫缺陷小鼠中诱导磷酸胆碱特异性抗体：对肺炎链球菌攻击的体内保护作用。
Int Immunol. 1994 Apr;6(4):561-8. doi: 10.1093/intimm/6.4.561.
10
Mouse antibody to phosphocholine can protect mice from infection with mouse-virulent human isolates of Streptococcus pneumoniae.抗磷酸胆碱的小鼠抗体可保护小鼠免受小鼠强毒株型肺炎链球菌人类分离株的感染。
Infect Immun. 1992 May;60(5):1957-62. doi: 10.1128/iai.60.5.1957-1962.1992.
引用本文的文献
1
Splenic red pulp macrophages eliminate the liver-resistant from the blood circulation of mice.脾脏红髓巨噬细胞清除小鼠血液循环中肝脏抗性物质。
Sci Adv. 2025 Mar 14;11(11):eadq6399. doi: 10.1126/sciadv.adq6399. Epub 2025 Mar 12.
2
Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia.布鲁顿酪氨酸激酶介导的髓系细胞信号传导在肺炎球菌肺炎期间的保护性固有免疫中是必需的。
Front Immunol. 2021 Sep 6;12:723967. doi: 10.3389/fimmu.2021.723967. eCollection 2021.
3
Long-term Immunotoxic Effects of Oral Prenatal and Neonatal Atrazine Exposure.长期经口产前和新生儿暴露于莠去津的免疫毒性作用。
Toxicol Sci. 2019 Apr 1;168(2):497-507. doi: 10.1093/toxsci/kfz005.
4
PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.程序性死亡配体2通过白细胞介素-5依赖机制调节B-1细胞针对磷酸胆碱的抗体产生。
J Immunol. 2017 Sep 15;199(6):2020-2029. doi: 10.4049/jimmunol.1700555. Epub 2017 Aug 2.
5
Vaccine against arteriosclerosis: an update.抗动脉粥样硬化疫苗：最新进展
Ther Adv Vaccines. 2017 Apr;5(2):39-47. doi: 10.1177/2051013617693753. Epub 2017 Feb 1.
6
The Pathogenic Potential of a Microbe.微生物的致病潜力
mSphere. 2017 Feb 22;2(1). doi: 10.1128/mSphere.00015-17. eCollection 2017 Jan-Feb.
7
Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice.跨膜激活剂和钙调素配体相互作用分子A144E的杂合性导致小鼠单倍剂量不足和对肺炎球菌易感。
J Allergy Clin Immunol. 2017 Apr;139(4):1293-1301.e4. doi: 10.1016/j.jaci.2016.07.028. Epub 2016 Sep 5.
8
IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens.IRAK-4和MyD88缺陷会损害针对非T细胞依赖性细菌抗原的IgM反应。
Blood. 2014 Dec 4;124(24):3561-71. doi: 10.1182/blood-2014-07-587824. Epub 2014 Oct 15.
9
Advances in immune-modulating therapies to treat atherosclerotic cardiovascular diseases.用于治疗动脉粥样硬化性心血管疾病的免疫调节疗法的进展。
Ther Adv Vaccines. 2014 Mar;2(2):56-66. doi: 10.1177/2051013613514327.
10
A modified surface killing assay (MSKA) as a functional in vitro assay for identifying protective antibodies against pneumococcal surface protein A (PspA).一种改良的表面杀伤测定法（MSKA）作为一种功能性的体外测定法，用于鉴定针对肺炎球菌表面蛋白 A（PspA）的保护性抗体。
Vaccine. 2013 Dec 17;32(1):39-47. doi: 10.1016/j.vaccine.2013.10.080. Epub 2013 Nov 6.
本文引用的文献
1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
2
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.在正常小鼠血清中发现的抗磷酸胆碱抗体可预防3型肺炎链球菌的静脉感染。
J Exp Med. 1981 Mar 1;153(3):694-705. doi: 10.1084/jem.153.3.694.
3
Nature of the cross-protective antigen in subcellular vaccines of Streptococcus pneumoniae.肺炎链球菌亚细胞疫苗中交叉保护性抗原的性质。
Infect Immun. 1981 Jan;31(1):160-8. doi: 10.1128/iai.31.1.160-168.1981.
4
Phagocytosis and killing of salmonella typhimurium by peritoneal exudate cells.腹膜渗出细胞对鼠伤寒沙门氏菌的吞噬与杀灭作用
Infect Immun. 1981 Aug;33(2):380-8. doi: 10.1128/iai.33.2.380-388.1981.
5
Anti-phosphocholine hybridoma antibodies. I. Direct evidence for three distinct families of antibodies in the murine response.抗磷酸胆碱杂交瘤抗体。I. 小鼠应答中三种不同抗体家族的直接证据。
J Exp Med. 1981 Feb 1;153(2):352-64. doi: 10.1084/jem.153.2.352.
6
Mouse Igg3 antibodies are highly protective against infection with Streptococcus pneumoniae.小鼠IgG3抗体对肺炎链球菌感染具有高度保护作用。
Nature. 1981 Nov 5;294(5836):88-90. doi: 10.1038/294088a0.
7
A simplification of the radioactive antigen-binding test by a double label technique.采用双标记技术对放射免疫结合试验的简化。
J Immunol. 1971 Sep;107(3):910-1.
8
Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate.肺炎球菌C物质，一种含磷酸胆碱的核糖醇壁酸。
Biochem J. 1968 Dec;110(3):573-82. doi: 10.1042/bj1100573.
9
Pneumococcal Forssman antigen. A choline-containing lipoteichoic acid.肺炎球菌福斯曼抗原。一种含胆碱的脂磷壁酸。
J Biol Chem. 1973 Sep 25;248(18):6394-7.
10
Immune response deficiency of BSVS mice. II. Generalized deficiency to thymus-dependent antigens.BSVS小鼠的免疫反应缺陷。II. 对胸腺依赖性抗原的全身性缺陷。
Eur J Immunol. 1979 Apr;9(4):255-61. doi: 10.1002/eji.1830090402.
Zotero 插件