Briles D E, Lehmeyer J, Forman C
Infect Immun. 1981 Aug;33(2):380-8. doi: 10.1128/iai.33.2.380-388.1981.
Normal peritoneal cells from conventional, germfree, or nu/nu mice readily killed opsonized salmonellae, an observation that suggests that this activity in the normal peritoneal cavity may not be dependent on either environmental antigenic stimulation or T-cell mediation. In contrast, peritoneal cells elicited 4 days after injection with thioglycolate medium failed to kill opsonized salmonellae but appeared to be highly phagocytic. Peritoneal cells from thioglycolate-treated mice could be induced to kill opsonized salmonellae by giving the mice a primary footpad injection and a secondary intraperitoneal injection of Corynebacterium parvum. This activation by C. parvum appeared to be thymus dependent, since it did not occur in nu/nu mice.
来自常规饲养、无菌或裸鼠的正常腹膜细胞能够轻易杀死经调理素作用的沙门氏菌，这一观察结果表明，正常腹膜腔中的这种活性可能既不依赖于环境抗原刺激，也不依赖于T细胞介导。相比之下，在注射巯基乙酸盐培养基4天后诱导产生的腹膜细胞无法杀死经调理素作用的沙门氏菌，但似乎具有高度吞噬作用。通过给经巯基乙酸盐处理的小鼠进行初次足垫注射和二次腹腔注射微小棒状杆菌，可诱导其腹膜细胞杀死经调理素作用的沙门氏菌。微小棒状杆菌的这种激活作用似乎依赖于胸腺，因为在裸鼠中不会发生这种情况。
