Cochran S T, Norman A
Invest Radiol. 1982 Mar-Apr;17(2):178-82. doi: 10.1097/00004424-198203000-00012.
Acentric chromosome fragments produced in cells by irradiation or other agents give rise to micronuclei in daughter cells. The micronuclei can be readily counted in large numbers of cells thereby providing a sensitive measure of chromosome aberrations. Previous studies have shown a consistent elevation of micronuclei count following the use of diatrizoate contrast materials. This study was undertaken to compare the micronuclei counts of patients receiving sodium iothalamate with those receiving sodium diatrizoate. Our results indicate that sodium diatrizoate produced significantly greater cytogenetic damage than the sodium iothalamate agents.
由辐射或其他因素在细胞中产生的无着丝粒染色体片段会在子细胞中形成微核。微核可以在大量细胞中轻松计数，从而提供一种检测染色体畸变的灵敏方法。先前的研究表明，使用泛影酸盐造影剂后微核计数会持续升高。本研究旨在比较接受碘他拉酸钠和接受泛影酸钠的患者的微核计数。我们的结果表明，泛影酸钠比碘他拉酸钠制剂产生的细胞遗传学损伤明显更大。
