Mozdarani H, Fadaei S
Department of Radiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
Toxicol Lett. 1998 Sep 1;98(1-2):25-30. doi: 10.1016/s0378-4274(98)00043-5.
Cytogenetic effects of two ionic contrast media (CM), Urografin 76% a sodium-meglumine diatrizoate, and Telebrix 38, a sodium-meglumine ioxythalamate, were tested on lymphocytes of patients undergoing brain CT Scan. Both compounds have approximately similar iodine concentrations. Chromosomal aberrations were scored in peripheral lymphocytes obtained from 15 patients undergoing brain CT with either urografin 76% or telebrix 38 before and after examination. Results showed no difference in aberration frequency for patients who underwent brain CT without contrast materials compared to controls. However, injection of CM resulted in a high frequency of chromosomal aberrations which significantly differed from controls (P < 0.05). The effect of urografin 76% appeared to be similar to telebrix 38. Therefore, both CM exhibited clastogenic effects on peripheral lymphocytes in vivo. An increase in chromosomal aberrations due to CM used in this study were similar to that reported for other ionic and non-ionic compounds.
在接受脑部CT扫描的患者淋巴细胞上测试了两种离子型造影剂（CM）的细胞遗传学效应，即76%泛影葡胺（一种钠-葡甲胺双醋碘苯酸盐）和38%碘多啥胺（一种钠-葡甲胺异泛影酸盐）。这两种化合物的碘浓度大致相似。对15名接受脑部CT扫描并使用76%泛影葡胺或38%碘多啥胺的患者，在检查前后采集外周淋巴细胞，对染色体畸变进行评分。结果显示，与对照组相比，未使用造影剂接受脑部CT扫描的患者畸变频率没有差异。然而，注射造影剂导致染色体畸变频率升高，与对照组有显著差异（P<0.05）。76%泛影葡胺的效应似乎与38%碘多啥胺相似。因此，两种造影剂在体内对外周淋巴细胞均表现出致断裂效应。本研究中使用的造影剂导致的染色体畸变增加与其他离子型和非离子型化合物的报道相似。
