Hoyes A D, Barber P, Jagessar H
J Anat. 1982 Mar;134(Pt 2):265-71.
The numbers of axons/unit length and of axons/group in the epithelium of the right and left sides of the trachea were determined in longitudinally orientated sections of specimens taken from five control rats, and from groups of five or six rats three days after section of the left vagus nerve above or below the nodose ganglion or section of the superior laryngeal and pharyngeal branches of the left vagus. After section of the vagus nerve below the nodose ganglion, there was a highly significant reduction in the number of axons/unit length in the epithelium of the ipsilateral side of the trachea, a significant reduction in the number of axons/group on this side and a small reduction in the number of axons/unit length on the contralateral side. The absence of similar changes in specimens from rats in which the vagus nerve was sectioned above the nodose ganglion, and in rats in which the branches from the ganglion were sectioned, indicated that the intraepithelial axons are derived from neurons whose perikarya are located in the ganglion and is consistent with the view that the axons are afferent. In addition to axons with terminals which resembled those which, in other tissues, have been defined as pain afferents, occasional axons with terminals containing numerous small clear vesicles were identified in the epithelium. The absence of these axons from the epithelium only in specimens taken from the ipsilateral side of the trachea after infranodose section of the left vagus nerve suggests that these may also be afferent.
在取自五只对照大鼠以及五或六只大鼠组的标本纵向切片中，测定了气管左右两侧上皮中轴突的单位长度数量和轴突的每组数量。这些大鼠组分别在结节神经节上方或下方切断左侧迷走神经，或切断左侧迷走神经的喉上支和咽支三天后进行取材。在结节神经节下方切断迷走神经后，气管同侧上皮中轴突的单位长度数量显著减少，该侧轴突的每组数量显著减少，对侧轴突的单位长度数量略有减少。在结节神经节上方切断迷走神经的大鼠标本以及切断神经节分支的大鼠标本中未出现类似变化，这表明上皮内轴突源自其胞体位于神经节的神经元，这与轴突是传入性的观点一致。除了具有类似于在其他组织中被定义为痛觉传入纤维终末的轴突外，在上皮中还识别出偶尔具有含有许多小而清亮囊泡终末的轴突。仅在左侧迷走神经结节下切断后取自气管同侧的标本上皮中没有这些轴突，这表明这些轴突可能也是传入性的。
