Lumholtz I B, Faber J, Kirkegaard C, Siersbaek-Nielsen K, Friis T
J Clin Endocrinol Metab. 1982 Jun;54(6):1097-100. doi: 10.1210/jcem-54-6-1097.
The effect of D,L-propranolol (80 mg daily) on the peripheral monodeiodination of rT3, 3',5'-diiodothyronine (3',5'-T2), 3,3'-diiodothyronine (3,3'-T2), and 3'-monoiodothyronine (3'-T1) was studied in seven out-patients with severe pretreatment hypothyroidism. The patients were maintained euthyroid on a constant L-T4 replacement therapy. A bolus injection technique was used; MCR, production rate (PR), and conversion rate were determined using a noncompartmental kinetic model. During D,L-propranolol, serum rT3 and 3',5'-T2 increased (P less than 0.02), and 3,3'-T2 seemed to decrease. The MCRs of rT3, 3',5'-T2, and 3,3'-T2 (P less than 0.02) decreased during drug treatment. The MCR and PR of 3'-T1 were reduced, albeit not significantly (P less than 0.10). The PR of 3,3'-T2 was reduced (P less than 0.02), whereas the PRs of rT3 and 3',5'-T2 were unaltered. The conversion rate of rT3 to 3',5'-T2 was unaltered. No changes were seen in the apparent distribution volumes of the iodothyronines studied. The results are compatible with the assumption that D,L-propranolol, or a metabolite thereof, inhibits the 5'-deiodination of all of the iodothyronines.
研究了D,L-普萘洛尔（每日80毫克）对7例重度甲状腺功能减退症门诊患者外周血中反式三碘甲状腺原氨酸（rT3）、3',5'-二碘甲腺原氨酸（3',5'-T2）、3,3'-二碘甲腺原氨酸（3,3'-T2）和3'-单碘甲腺原氨酸（3'-T1）单脱碘作用的影响。这些患者在持续的左旋甲状腺素（L-T4）替代治疗下维持甲状腺功能正常。采用了静脉推注技术；使用非房室动力学模型测定了代谢清除率（MCR）、生成率（PR）和转化率。在服用D,L-普萘洛尔期间，血清rT3和3',5'-T2升高（P<0.02），3,3'-T2似乎降低。药物治疗期间，rT3、3',5'-T2和3,3'-T2的MCR降低（P<0.02）。3'-T1的MCR和PR降低，尽管不显著（P<0.10）。3,3'-T2的PR降低（P<0.02），而rT3和3',5'-T2的PR未改变。rT3向3',5'-T2的转化率未改变。所研究的碘甲腺原氨酸的表观分布容积未见变化。结果与以下假设一致，即D,L-普萘洛尔或其代谢产物抑制所有碘甲腺原氨酸的5'-脱碘作用。
