Demura R, Ono M, Demura H, Shizume K, Oouchi H
J Clin Endocrinol Metab. 1982 Jun;54(6):1246-50. doi: 10.1210/jcem-54-6-1246.
An ovarian perifusion technique was used to determine if there is a direct suppressive effect of PRL on human gonadal steroid secretion. Ovarian tissue from nine patients was examined. Ovine PRL (0.1-10 IU/ml) directly suppressed progesterone and 17 beta-estradiol secretion by human ovaries. hCG (1-10 IU/ml) stimulated both progesterone and 17 beta-estradiol secretion. Simultaneous administration of PRL (5-10 IU/ml) suppressed the stimulatory effect of hCG. The ovarian tissue obtained from a hyperprolactinemic patient did not respond to hCG. These results indicate that PRL inhibits both basal and gonadotropin-stimulated ovarian steroid secretion by human ovaries and that this may be one cause of the hypogonadism associated with hyperprolactinemia.
采用卵巢灌注技术来确定催乳素（PRL）对人类性腺甾体分泌是否有直接抑制作用。检测了9名患者的卵巢组织。绵羊PRL（0.1 - 10国际单位/毫升）直接抑制人类卵巢孕酮和17β-雌二醇的分泌。人绒毛膜促性腺激素（hCG，1 - 10国际单位/毫升）刺激孕酮和17β-雌二醇的分泌。同时给予PRL（5 - 10国际单位/毫升）可抑制hCG的刺激作用。从一名高催乳素血症患者获得的卵巢组织对hCG无反应。这些结果表明，PRL抑制人类卵巢基础状态下以及促性腺激素刺激下的甾体分泌，这可能是高催乳素血症相关性腺功能减退的原因之一。
