Ribak C E, Fallon J H
J Comp Neurol. 1982 Mar 1;205(3):207-18. doi: 10.1002/cne.902050302.
An analysis of the cells and their processes within the island of Calleja complexes (ICC) was made in light and electron microscopic preparations to determine synaptic relationships within this part of the basal forebrain. The light microscopic preparations showed that the ICC contained two cell types, granule cells and large cells. In electron microscopic preparations, the somata of granule cells were grouped together and were directly apposed to other somata of granule cells. Specialized junctions (4-6 nm wide) that occurred at sites of somal apposition suggested ephaptic coupling of granule cells. The granule cell somata had nuclei that contained clumps of heterochromatin adjacent to smooth nuclear envelopes. The perikaryal cytoplasm of these cells consisted of a relatively thin rim containing few organelles. Spinous dendrites of small diameter were occasionally found in continuity with these cells. Axon terminals rarely formed synapses with the somata of granule cells, but were more frequently found to synapse on their dendrites and dendritic spines. These features for granule cells are similar to those for medium-sized spiny neurons in the neostriatum. The somata of the large cells were found either within the core or along the dorsal margin of the ICC. The large cells had infolded nuclei and an abundant perikaryal cytoplasm that contained many organelles. Large diameter dendrites that tapered down to smaller diameters emanated in many directions from these somata. Axon terminals covered nearly the entire surface of these somata and dendrites where they commonly formed symmetric synaptic junctions. These characteristics of large cells indicate a resemblance to the large cells in the globus pallidus and ventral pallidum. Therefore, the ICC have ultrastructural features found in both the neostriatum and globus pallidus.
为确定基底前脑这一部分内的突触关系，我们对卡勒哈岛复合体（ICC）内的细胞及其突起进行了光镜和电镜观察分析。光镜观察显示，ICC包含两种细胞类型，即颗粒细胞和大细胞。在电镜观察中，颗粒细胞的胞体聚集在一起，并直接与其他颗粒细胞的胞体相邻。在胞体相邻处出现的特殊连接（宽4 - 6纳米）提示颗粒细胞之间存在电突触耦合。颗粒细胞的胞体有细胞核，核内含有靠近光滑核膜的异染色质团块。这些细胞的核周细胞质由相对较薄的边缘组成，含有很少的细胞器。偶尔会发现小直径的棘状树突与这些细胞相连。轴突终末很少与颗粒细胞的胞体形成突触，但更常见于与它们的树突和树突棘形成突触。颗粒细胞的这些特征与新纹状体中的中型棘状神经元相似。大细胞的胞体要么位于ICC的核心内，要么沿着其背侧边缘分布。大细胞的核有内陷，核周细胞质丰富，含有许多细胞器。从这些胞体向多个方向发出大直径的树突，这些树突逐渐变细至较小直径。轴突终末几乎覆盖了这些胞体和树突的整个表面，在那里它们通常形成对称的突触连接。大细胞的这些特征表明它们与苍白球和腹侧苍白球中的大细胞相似。因此，ICC具有新纹状体和苍白球中发现的超微结构特征。
