Mertz G J, Nelson K E, Vithayasai V, Makornkawkeyoon S, Rosanoff E I, Tint H, Wiktor T J
J Infect Dis. 1982 May;145(5):720-7. doi: 10.1093/infdis/145.2.720.
One hundred one volunteers with no exposure to rabies were given human diploid cell vaccine (HDCV) for rabies with or without 20 international units of human rabies immune globulin (HRIG)/kg of body weight to evaluate schedules for therapy with HDCV and HRIG after exposure. All of the volunteers who received three or more doses of HDCV alone or four or more doses of HDCV with HRIG developed high titers of neutralizing antibodies by day 35, which persisted for at least 60 days. By day 7, of the 61 volunteers given HRIG and HDCV, 53% had neutralizing antibodies by a mouse neutralization test and 67% had neutralizing antibodies by a rapid fluorescent focus inhibition test. Similar antibody levels were found in volunteers given HRIG alone, a finding which suggests that low or undetectable early titers after administration of HDCV and HRIG were due to inadequate HRIG dosage rather than any interaction between the passive antibody (HRIG) and the vaccine antigen. These results suggest that trials with 30 or 40 international units of HRIG/kg in combination with HDCV are warranted.
101名未接触过狂犬病的志愿者接受了人用狂犬病疫苗（HDCV），部分志愿者同时接受了20国际单位/千克体重的人狂犬病免疫球蛋白（HRIG），以评估暴露后HDCV和HRIG的治疗方案。所有单独接受三剂或更多剂HDCV或接受四剂或更多剂HDCV加HRIG的志愿者在第35天时均产生了高滴度的中和抗体，且至少持续60天。在接受HRIG和HDCV的61名志愿者中，到第7天时，53%的志愿者通过小鼠中和试验检测到中和抗体，67%的志愿者通过快速荧光灶抑制试验检测到中和抗体。单独接受HRIG的志愿者也发现了类似的抗体水平，这一发现表明，HDCV和HRIG给药后早期滴度低或检测不到是由于HRIG剂量不足，而非被动抗体（HRIG）与疫苗抗原之间存在任何相互作用。这些结果表明，有必要进行HRIG剂量为30或40国际单位/千克与HDCV联合使用的试验。
