MRL小鼠中类风湿因子同种型和特异性的异质性。
Heterogeneity in rheumatoid factor isotypes and specificities in MRL mice.
作者信息
Bond A, Cooke A, Hay F C
机构信息
Department of Immunology, University College and Middlesex School of Medicine, London, U.K.
出版信息
Immunology. 1988 May;64(1):17-21.
MRL/lpr mice spontaneously develop an arthritis which, in several respects, is similar to human rheumatoid arthritis, including joint inflammation and circulating rheumatoid factors. In human disease, circulating IgM rheumatoid factor (RF) predominates but, surprisingly, in these mice we have detected much more IgA rheumatoid factor. This IgA rheumatoid factor has a major specificity for IgG2a, but heterogeneity in binding specificity was seen between different mice. IgG rheumatoid factors were determined in a heterologous mouse IgG assay, in which each subclass of rheumatoid factor was tested for its ability to bind to the remaining IgG subclasses. Rheumatoid factor activity was detected in all the IgG subclasses, but particularly elevated levels were seen in IgG3 and IgG1. Both the levels and specificities of IgG rheumatoid factors were markedly different between each mouse.
MRL/lpr小鼠会自发患上一种关节炎，在几个方面与人类类风湿性关节炎相似，包括关节炎症和循环类风湿因子。在人类疾病中，循环IgM类风湿因子（RF）占主导，但令人惊讶的是，在这些小鼠中我们检测到了更多的IgA类风湿因子。这种IgA类风湿因子对IgG2a具有主要特异性，但不同小鼠之间在结合特异性上存在异质性。通过异源小鼠IgG检测法测定IgG类风湿因子，其中测试每种类风湿因子亚类与其余IgG亚类结合的能力。在所有IgG亚类中均检测到类风湿因子活性，但在IgG3和IgG1中水平尤其升高。每只小鼠之间IgG类风湿因子的水平和特异性均明显不同。
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