Ko M L, King M A, Gordon T L, Crisp T
Department of Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-0095, USA.
Brain Res Bull. 1997;42(2):95-8. doi: 10.1016/s0361-9230(96)00216-x.
The purpose of this study was to investigate how the aging process alters the basal levels of serotonin, norepinephrine, dopamine, and their respective metabolites in the spinal cord using high-performance liquid chromatography and electrochemical detection. Young, mature and aged male Fischer 344 rats (5-6, 15-16, and 25-26 months old, respectively) were used in all experiments. Dorsal and ventral halves of the cervical, thoracic, lumbar and sacral vertebral sections of the rat spinal cord were analyzed. The results indicate that as chronological age increases, local spinal levels of serotonin and norepinephrine decrease. These findings are discussed in terms of how age-related changes in the endogenous levels of the biogenic amines may alter the perception of pain in the elderly.
本研究的目的是利用高效液相色谱法和电化学检测技术，研究衰老过程如何改变脊髓中血清素、去甲肾上腺素、多巴胺及其各自代谢物的基础水平。所有实验均使用年轻、成熟和老年雄性Fischer 344大鼠（分别为5 - 6个月、15 - 16个月和25 - 26个月大）。对大鼠脊髓颈、胸、腰和骶椎节段的背侧和腹侧部分进行了分析。结果表明，随着实际年龄的增加，脊髓局部血清素和去甲肾上腺素水平降低。本文根据生物胺内源性水平的年龄相关变化如何改变老年人的疼痛感知对这些发现进行了讨论。
