McDougall I R, Bayer M F, Nierenberg D, Lewis S J
J Nucl Med. 1982 Jun;23(6):507-10.
Free thyroxine (FT4) has been measured in two groups of patients, before and after heparin, using equilibrium dialysis (ED) and two radioimmunoassays, RIA-I and RIA-II. In Group A, nine patients were tested before and after 12-24 hr of intravenous heparin, FT4 (ED) rose from 1.9 +/- 0.5 to 2.8 +/- 3.0 ng/dl, and RIA-I from 1.37 +/- 0.37 to 1.89 +/- 1.21 ng/dl, whereas RIA-II results fell from 0.97 +/- 0.38 to 0.66 +/- 0.32 ng/dl. In Group B, ten patients were tested before and after 15 min of intravenous heparin. FT4 (ED) rose from 1.7 +/- 0.7 to 3.2 +/- 1.6 ng/dl (p less than 0.02), and RIA-I rose from 1.3 +/- 0.46 to 2.02 +/- 0.01 ng/dl (P less than 0.05), whereas RIA-II results fell from 1.07 +/- 0.38 to 0.63 +/- 0.31 ng/dl (P less than 0.02). The correlation coefficient between FT4 (ED) and RIA-I in 38 paired results was 0.96, but there was no correlation between FT4 (ED) and RIA-II results.
使用平衡透析法（ED）以及两种放射免疫分析法（RIA-I和RIA-II），对两组患者在使用肝素前后的游离甲状腺素（FT4）进行了测定。A组中，9名患者在静脉注射肝素12至24小时前后接受了检测，FT4（ED）从1.9±0.5升至2.8±3.0 ng/dl，RIA-I从1.37±0.37升至1.89±1.21 ng/dl，而RIA-II的结果则从0.97±0.38降至0.66±0.32 ng/dl。B组中，10名患者在静脉注射肝素15分钟前后接受了检测。FT4（ED）从1.7±0.7升至3.2±1.6 ng/dl（p<0.02），RIA-I从1.3±0.46升至2.02±0.01 ng/dl（P<0.05），而RIA-II的结果则从1.07±0.38降至0.63±0.31 ng/dl（P<0.02）。在38对结果中，FT4（ED）与RIA-I之间的相关系数为0.96，但FT4（ED）与RIA-II的结果之间无相关性。
