Zamenhof S, van Marthens E
J Nutr. 1982 May;112(5):972-7. doi: 10.1093/jn/112.5.972.
The effect on aging and survival of mild (2/3 of ad lib) chronic prenatal and postnatal undernutrition over 10 generations, or prenatal undernutrition only has been studied in rats. Both regimes of undernutrition used decreased body weights of animals as compared to the controls. Both undernourished groups had lower cholesterol levels and tumor incidence than the controls. The effects on survival depended not only on the time period of undernutrition but also on the age of the animals examined: chronic undernutrition resulted in lower survival of young adult animals (4-8 months) but higher survival than the controls in old age. Prenatal undernutrition only had no effect on young adult animals, gave higher survival than the controls at ages 8-18 months but considerably lower survival than controls in the old age: the underdevelopment of vital organs whose cells proliferate only before birth might have been the cause of such decreased longevity.
在大鼠中研究了轻度（自由摄食量的2/3）慢性产前和产后营养不足持续10代对衰老和存活的影响，或仅研究了产前营养不足的影响。与对照组相比，所采用的两种营养不足方案均降低了动物的体重。两个营养不足组的胆固醇水平和肿瘤发生率均低于对照组。对存活的影响不仅取决于营养不足的时间段，还取决于所检查动物的年龄：慢性营养不足导致年轻成年动物（4 - 8个月）存活率降低，但老年时存活率高于对照组。仅产前营养不足对年轻成年动物没有影响，在8 - 18个月龄时存活率高于对照组，但老年时存活率远低于对照组：重要器官发育不全，其细胞仅在出生前增殖，可能是寿命缩短的原因。
