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慢性营养不良对青年成年大鼠和老年大鼠冷应激易感性的影响。

Effect of chronic undernutrition on susceptibility to cold stress in young adult and aged rats.

作者信息

Campbell B A, Richardson R

机构信息

Department of Psychology, Princeton University, NJ 08544.

出版信息

Mech Ageing Dev. 1988 Aug;44(2):193-202. doi: 10.1016/0047-6374(88)90091-7.

DOI:10.1016/0047-6374(88)90091-7
PMID:3172863
Abstract

Chronically undernourished laboratory rodents live as much as 50% longer than matched control animals fed ad libitum. In their natural habitats, however, most mammals, including humans, appear to have shorter life expectancies when chronically undernourished. The present research demonstrated that both brief and chronic undernutrition speeds rate of body temperature drop in rats exposed to cold air. Furthermore, chronic undernutrition also decreased the rate at which body temperature returned to normal after animals had been removed from the cold environment. These results suggest that while chronic undernutrition may slow the rate of physiological aging it also increases the organism's susceptibility to stressor stimuli.

摘要

长期营养不良的实验啮齿动物比随意进食的对照动物寿命长50%。然而,在它们的自然栖息地,包括人类在内的大多数哺乳动物,长期营养不良时似乎预期寿命较短。目前的研究表明,短期和长期营养不良都会加快暴露在冷空气中的大鼠体温下降速度。此外,长期营养不良还会降低动物从寒冷环境中移出后体温恢复正常的速度。这些结果表明,虽然长期营养不良可能会减缓生理衰老速度,但也会增加生物体对应激刺激的易感性。

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