Migally N, Tucker A, Zambernard J
J Submicrosc Cytol. 1982 Apr;14(2):247-52.
The pulmonary trunk, muscular arteries, and arterioles of male Sprague-Dawley rats exposed to simulated high altitude hypoxia (380 mm Hg) for six weeks were studied for glycogen localization. As early as three days exposure time, glycogen particles were mobilized in the smooth muscle cells of muscular arteries and arterioles. Weekly sacrifice of animals showed increasing preferential accumulation of glycogen, near the sarcoplasmic reticulum, in the subsarcolemmal region, adjacent to micropinocytotic vesicles, and near the mitochondria in the smooth muscle cells of muscular arteries and arterioles. However, in the smooth muscle cells of the pulmonary trunk and newly muscularized vessels (arteries and arterioles), glycogen storage was not readily noted. These results suggests that the vascular energetics responsible for maintaining the pulmonary hypertensive state differ depending on the class of vessel. Also the muscular pulmonary arteries and arterioles which exhibited the greatest change in glycogen metabolism, may be primarily responsible for the maintenance of pulmonary hypertension.
对暴露于模拟高原低氧环境（380毫米汞柱）六周的雄性斯普拉格-道利大鼠的肺动脉干、肌性动脉和小动脉进行糖原定位研究。早在暴露三天时，肌性动脉和小动脉的平滑肌细胞中的糖原颗粒就开始动员。每周处死动物显示，肌性动脉和小动脉的平滑肌细胞中，糖原在肌浆网附近、肌膜下区域、微吞饮小泡附近以及线粒体附近的优先积累不断增加。然而，在肺动脉干和平滑肌新形成的血管（动脉和小动脉）的平滑肌细胞中，未观察到糖原储存。这些结果表明，维持肺动脉高压状态的血管能量学因血管类型而异。此外，糖原代谢变化最大的肌性肺动脉和小动脉可能是维持肺动脉高压的主要原因。
