Migally N, Tucker A, Zambernard J
J Submicrosc Cytol. 1982 Apr;14(2):239-46.
The pulmonary veins of male Swiss albino mice, exposed to simulated high altitude (380 mm Hg) for four weeks were studied for structural alterations. Endothelial cells contained invaginated nuclei and an accumulation of vesicles on the adluminal surfaces. In the subendothelial region, cells which contained filaments and dense bodies were noted. Increased muscular contraction, evidenced by decrease in the width of the I-band of the sarcomere, caveolae formation, sarcolemmal invaginations, and glycogen deposition were the most evident changes in the cardiac muscle layer. These alterations were interpreted as possible morphologically adaptive changes of pulmonary venous pulmonary vasoconstriction in response to increased metabolic demands as a result of changes in pulmonary hemodynamics with chronic hypoxia.
对暴露于模拟高海拔（380毫米汞柱）四周的雄性瑞士白化小鼠的肺静脉进行了结构改变研究。内皮细胞含有内陷的细胞核，在管腔表面有大量小泡聚集。在内皮下区域，发现了含有细丝和致密小体的细胞。肌节I带宽度减小、小窝形成、肌膜内陷和糖原沉积所证明的肌肉收缩增加是心肌层最明显的变化。这些改变被解释为慢性缺氧导致肺血流动力学变化，进而使代谢需求增加，肺静脉肺血管收缩可能出现的形态学适应性变化。
