Gendenshteĭn E I, Sernov L N
Kardiologiia. 1982 Apr;22(4):65-9.
The tolerance changes to strophanthin in cats were studied during 7 days after occlusion of the coronary artery along with the determination of the electrolyte concentration in different areas of the myocardium. It is shown that the acute disorder of the coronary circulation produces during 2 days considerable decrease of tolerance to the cardiotoxic action of strophanthin, which correlates with the electrolyte imbalance in the ischaemic and the adjacent areas of myocardium. Pharmacological analysis with the use of medicinal agents, possessing different properties established that the hypersensitivity to strophanthin in experimental myocardial infarction is an integral result of the influence of a number of factors, which when taken into account permit selection of rational medicinal correction of this phenomenon in different periods of acute myocardial ischaemia.
在冠状动脉闭塞后的7天内，研究了猫对毒毛花苷的耐受性变化，并测定了心肌不同区域的电解质浓度。结果表明，冠状动脉循环的急性紊乱在2天内会导致对毒毛花苷心脏毒性作用的耐受性显著降低，这与心肌缺血区和相邻区域的电解质失衡相关。使用具有不同特性的药物进行药理分析表明，实验性心肌梗死中对毒毛花苷的超敏反应是多种因素影响的综合结果，考虑到这些因素后，可以在急性心肌缺血的不同阶段选择合理的药物来纠正这一现象。
