Gendenshteĭn E I, Sernov L N, Alferov V F
Biull Eksp Biol Med. 1982 Mar;93(3):52-5.
Effects of histamine and serotonin on strophanthine cardiotoxicity were examined in experiments on 312 cats. It was shown that inflammation mediators exert sympathomimetic action on the myocardium and potentiate strophanthine cardiotoxicity. These effects can be prevented by premedication with the beta-blocker alprenolol, antihistaminic, steroid and non-steroidal anti-inflammatory agents. It was disclosed that premedication with diphenhydramine, analgin and hydrocortisone might correct strophanthine tolerance decreased as a result of coronary artery occlusion. The conclusion is made that inflammation mediators play a role in the genesis of strophanthine hypersensitivity in experimental myocardial infarction.
在312只猫身上进行的实验研究了组胺和5-羟色胺对毒毛花苷心脏毒性的影响。结果表明，炎症介质对心肌有拟交感神经作用，并增强毒毛花苷的心脏毒性。这些作用可通过预先使用β受体阻滞剂阿普洛尔、抗组胺药、类固醇和非类固醇抗炎药来预防。已发现预先使用苯海拉明、安乃近和氢化可的松可纠正因冠状动脉闭塞导致的毒毛花苷耐受性降低。得出的结论是，炎症介质在实验性心肌梗死中毒毛花苷超敏反应的发生过程中起作用。
