Gendenshteĭn E I, Sernov L N
Biull Eksp Biol Med. 1981 Jun;91(6):696-8.
Experiments on 176 cats with experimental myocardial infarction were made to study alterations in ouabain tolerance under pharmacological effects on extracardial innervation. It was shown that elimination of sympathetic innervation at different levels by benzohexonium, ornid and anapriline, as well as its relative weakening by proserine favoured the correction of hypersensitivity to ouabain in acute myocardial ischemia. Potentiation of sympatic effects by ephedrine and abolition of parasympathetic innervation by atropine increased ouabain cardiotoxicity.
对176只患有实验性心肌梗死的猫进行实验，以研究在心外神经支配受到药理作用时哇巴因耐受性的变化。结果表明，用溴化六甲铵、奥尼德和心得安在不同水平消除交感神经支配，以及用毒扁豆碱使其相对减弱，有利于纠正急性心肌缺血时对哇巴因的超敏反应。麻黄碱增强交感效应以及阿托品消除副交感神经支配会增加哇巴因的心脏毒性。
