Omanga U, Kageruka P, Tshishimbi M
Med Trop (Mars). 1982 Jan-Feb;42(1):19-25.
The authors report the results of a survey and a longitudinal study of mother-transmitted antimalarial antibodies, conducted through indirect immunofluorescence tests. The data indicate that 16 p. 100 of the new-born and 25 p. 100 of the considered age group get maternal antibodies either through transplacental way of through breast-feeding. Among 99 mothers having a positive antimalarial serology at their delivery, 30 have transmitted their antibodies to their infant. But whatever the way of transmission may be, these antibodies do not last longer, as a rule, than one month. If this passive immunity is either lacking or insufficient to protect the child, it seems that HbF has a great protective role, as indicated by the concordance between its decrease and the raise of malaria morbidity in children. As a consequence of the existence of a natural protection by HbF during the first three months of life, malarial prophylaxis does not seem necessary during this period.
作者报告了一项通过间接免疫荧光试验进行的关于母亲传播抗疟抗体的调查和纵向研究结果。数据表明，16%的新生儿和25%的相关年龄组通过胎盘途径或母乳喂养获得母体抗体。在99名分娩时抗疟血清学呈阳性的母亲中，有30名将抗体传给了婴儿。但无论传播方式如何，这些抗体通常不会持续超过一个月。如果这种被动免疫缺乏或不足以保护儿童，那么似乎胎儿血红蛋白（HbF）具有很大的保护作用，这从其水平下降与儿童疟疾发病率上升之间的一致性可以看出。由于在生命的前三个月存在胎儿血红蛋白的天然保护作用，在此期间似乎没有必要进行疟疾预防。
