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生活在疟疾稳定流行地区幼儿抗疟疾荧光抗体的演变(作者译)

[Antimalaria fluorescent antibodies evolution in young children living in a stable malaria area (author's transl)].

作者信息

Nozais J P, Ky D T, Doucet J

出版信息

Med Trop (Mars). 1979 Sep-Oct;39(5):549-53.

PMID:231178
Abstract

The detection of malarial fluorescent antibodies have been performed in an Abidjan dispensary on 30 newborn babies with their mothers, 30 children 3 months old and 120 children from 6 to 24 months. This survey took place during the small rainy season and it demonstrates that: --synthesis of specific antibodies is significantly starting after the 3rd month; --the rise, after six months, of the malarial antibodies is parallel to the plasmodic index checked during the same period in the same area; --the rate of antibodies in 2 years old babies is almost the same that in adults; --living conditions in rural areas accelerate the synthesis of antibodies which, adversely, is slowed down by regular chemoprophylaxis; --Plasmodium berghei is a valuable antigen for mass survey; --Abidjan town is an hypoendemic zone of stable malaria in a mesoendemic area.

摘要

在阿比让的一家诊疗所,对30名新生儿及其母亲、30名3个月大的儿童以及120名6至24个月大的儿童进行了疟原虫荧光抗体检测。这项调查在小雨季期间进行,结果表明:——特异性抗体的合成在3个月后显著开始;——6个月后,疟原虫抗体的上升与同一时期在同一地区检测的疟原虫指数平行;——2岁婴儿的抗体水平与成年人几乎相同;——农村地区的生活条件加速了抗体的合成,而定期化学预防则会对其产生不利影响,使其减缓;——伯氏疟原虫是大规模调查的一种有价值的抗原;——阿比让市是中流行区中稳定疟疾的低流行区。

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