Furness J B, Costa M
Neuroscience. 1982 Feb;7(2):341-9. doi: 10.1016/0306-4522(82)90271-8.
Changes in the distribution of 5-hydroxytryptamine-like immunoreactivity have been examined in enteric neurons at various times after microsurgical lesions of the enteric plexuses. In the myenteric plexus, varicose immunoreactive nerve fibres disappeared or were reduced in number in ganglia anal to an interruption of the myenteric plexus. Up to about 2 mm on the anal side, all varicose immunoreactive fibers disappeared from the ganglia. At about 14-16 mm below an interruption, there were about 50% of the normal number of fibres in the myenteric ganglia and at about 24 mm the innervation was normal. In the submucosa, fibres immunoreactive for 5-hydroxytryptamine were absent from an area on the anal side following interruption of the myenteric plexus. From consideration of the pattern of disappearance, it is deduced that some myenteric nerve cell bodies send immunoreactive axons in an anal direction to supply submucous ganglia. The axons run for about 8 mm in the myenteric plexus, enter the submucosa and then run for a further 4 mm approximately. Thus, varicose fibres immunoreactive for 5-hydroxytryptamine, which occur around the enteric ganglion cells of both plexuses arise from nerve cell bodies in myenteric ganglia than send their axons in an anal direction.
在肠丛显微手术损伤后的不同时间，对肠神经元中5-羟色胺样免疫反应性的分布变化进行了研究。在肌间神经丛中，在肌间神经丛中断平面以下的神经节中，曲张的免疫反应性神经纤维消失或数量减少。在中断平面以下约2毫米处，神经节中所有曲张的免疫反应性纤维均消失。在中断平面以下约14 - 16毫米处，肌间神经节中的纤维数量约为正常数量的50%，在约24毫米处神经支配正常。在黏膜下层，肌间神经丛中断后，中断平面以下区域不存在5-羟色胺免疫反应性纤维。从消失模式来看，可以推断一些肌间神经细胞体向肛门方向发出免疫反应性轴突以供应黏膜下神经节。轴突在肌间神经丛中走行约8毫米，进入黏膜下层，然后再走行约4毫米。因此，在两个神经丛的肠神经节细胞周围出现的5-羟色胺免疫反应性曲张纤维起源于肌间神经节中的神经细胞体，其轴突向肛门方向发出。
