Evans M J, Dekker N P, Cabral-Anderson L J, Freeman G
Am Rev Respir Dis. 1978 Oct;118(4):787-90. doi: 10.1164/arrd.1978.118.4.787.
The purpose of this study was to determine whether the amount of alveolar epithelial tissue damaged during exposure of NO2 could be quantified by measuring the proliferative response to Type 2 cells. To accomplishe this, we used tissues from previously published experiments in which rats had been exposed to NO2 and the proliferative response to Type 2 cells had been measured during a 5-day period. The proportion of alveolar epithelium damaged was determined by stereologic examination with electron microscopy of tissue sections from those rats exposed to NO2 for 24 hours. These values were then compared with the total proliferative response to Type 2 cells for the 5 days of exposure. The study demonstrated that increasing tissue damage is assocaited with a greater proliferative response to Type 2 cells. The high degree of correlation (r = 0.93) indicates that the proliferative response of Type 2 cells can be used as an indirect means to quantify acute damage to the alveolar epithelium.
本研究的目的是确定能否通过测量对2型细胞的增殖反应来量化二氧化氮暴露期间肺泡上皮组织受损的程度。为实现这一目的，我们使用了先前已发表实验中的组织，在这些实验中，大鼠暴露于二氧化氮，并在5天内测量了对2型细胞的增殖反应。通过对暴露于二氧化氮24小时的大鼠组织切片进行电子显微镜立体检查，确定受损肺泡上皮的比例。然后将这些值与暴露5天期间对2型细胞的总增殖反应进行比较。该研究表明，组织损伤增加与对2型细胞的增殖反应增强相关。高度相关性（r = 0.93）表明，2型细胞的增殖反应可作为量化肺泡上皮急性损伤的间接手段。
